
Sotalol hydrochloride
CAS No. 959-24-0
Sotalol hydrochloride( Betapace | MJ1999 )
Catalog No. M16847 CAS No. 959-24-0
Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Purity : >98% (HPLC)






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Biological Information
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Product NameSotalol hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
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DescriptionSotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.(In Vivo):Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin.
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In Vitro——
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In VivoSotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin. Animal Model:20-25 g female Swiss mice Dosage:100 mg/kg Administration:Administered intraperitoneally Result:Significantly decreased the brain concentrations of Lamotrigine and increased those of Oxcarbazepine and Topiramate.
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SynonymsBetapace | MJ1999
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PathwayEndocrinology/Hormones
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TargetAdrenergic Receptor
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Recptorβ-adrenergic receptor| Potassium Channel
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number959-24-0
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Formula Weight308.82
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Molecular FormulaC12H21ClN2O3S
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Purity>98% (HPLC)
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SolubilityWater: 62 mg/mL (200.76 mM); DMSO: 62 mg/mL (200.76 mM)
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SMILESCl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lowe MD, et al. Br J Pharmacol. 2002 Jan;135(2):451-6
molnova catalog



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